Silencing Metabolic Disorders by Novel SIRT1 Activators
نویسندگان
چکیده
منابع مشابه
Dietary activators of Sirt1.
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential ...
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Fasting triggers a complex metabolic programme in the liver to meet the emerging glucose deficit. this includes the immediate harvesting of glucose from glycogen and the activation of genes for gluco neogenesis. after more prolonged fasting, ketogenesis further augments the production of high-energy compounds for the brain and other tissues. at least two transcriptional pathways activate genes ...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2008
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2007.12.005